Ioflupane (123I) is the only approved imaging agent for this purpose; the European Medicines Agency (EMA) approved it under the trade name DaTSCAN (ioflupane (123I)) in 2000,11 and the US Food and Drug Administration (FDA) approved it under the trade name DaTscan (ioflupane I123 injection) in 2011.12 It is currently approved in 33 countries. We searched the literature and found numerous clinical trials that have been performed to establish the technical feasibility, diagnostic effectiveness, sensitivity and specificity of ioflupane (123I).13 43 However, each trial had limited numbers of participants for whom results were available, ranging from 16 to 326.37 ,15 Our search revealed that two meta analyses have been performed evaluating diagnostic accuracy of SPECT imaging in DLB and in PSs.44 ,45 However, no previous pooled data analysis had been undertaken and the aim of this study was to undertake a pooled analysis using the four clinical studies that were the large, multisite efficacy trials submitted to support the new drug application filing in the USA (three of them for EU) for licensing. They were conducted to the Good Clinical Practice (GCP) standards in predefined populations. cheap jerseys
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His appointment gets the BBC out of a massive hole. Clarkson had to be sacked for punching a producer in a row over hot food (or the lack of it, after a cold day’s filming) but killing the show off completely would have cost a fortune. Top Gear makes an estimated 50m a year for the Beeb in terms of overseas sales, not to mention merchandising, DVDs, books and live shows.